Therefore, elucidation of the mechanism of acetaminophen toxicity is an important matter for medical and pharmaceutical research. Although the precise mechanism is still unknown, oxidative damage ...

A new Israeli study reveals that paracetamol doesn’t function only in the brain; it also blocks pain at its source by acting on nerve endings in the body.

Scientists have known for decades that paracetamol in large amounts is toxic the liver, but until now its mechanism of poisoning has eluded them. Studies have shown significant hepatotoxicity is ...

As with acetaminophen, troglitazone's toxicity has been attributed to a bioactivation mechanism, in which the drug's reactive metabolites bind to cell proteins and the resulting complexes somehow ...

A discussion of the clinical problem and the mechanism of benefit of this ... estimate the likelihood of hepatic injury due to acetaminophen toxicity for patients with a single ingestion at ...

Acetaminophen poisoning (APAP) is the second most common ... research is now being conducted to determine exactly which mechanisms of transient bile stasis after APAP poisoning contribute to ...

Regardless of its similarities to NSAIDs, its mechanism of action was formerly ... However, in the case of paracetamol overdose, this metabolite is not detoxified effectively and it may cause ...

The ability of the liver to metabolize acetaminophen changes with age owing to differences in activity of these key metabolic pathways. Although the mechanism of acetaminophen toxicity is well ...

Poisoning caused by taking too much paracetamol can damage the liver ... technology are enabling a fuller picture of the biological mechanisms involved." The study, involving researchers from ...