Early and accurate diagnosis hinges on recognizing hallmark features such as elevated hematocrit, JAK2 mutations (particularly JAK2 V617F), and bone marrow morphology consistent with panmyelosis.

• Hgb > 18.5 g/dl (men) or > 16.5 g/dl (women) or Hgb or Hct > 99th percentile of method-specific reference range for age, sex or altitude of residence or Hgb > 17 g/dl (men) or > 15 g/dl (women ...

“Serum erythropoietin was tested low (1.8 mIU/mL), and a bone marrow (BM) biopsy was carried out at the same time, revealing panmyelosis (hypercellularity with trilineage growth), megakaryocytic ...

A recent study suggests that non–driver mutations may hold prognostic value in essential thrombocythemia (ET) and polycythemia vera (PV), both of which are Philadelphia chromosome–negative ...

The leukocyte alkaline phosphate score was 10/58. A bone marrow examination showed marked granulocytic and megakaryocytic hyperplasia with panmyelosis and no increase in blasts. Karyotyping showed ...

Megakaryocytic blast crisis has a characteristically low incidence and may prove to be a diagnostic challenge for the clinicians and the pathologists especially in previously undetected CML cases. The ...

Acute panmyelosis with myelofibrosis (APMF) is a subtype of acute myeloid leukemia (AML) classified among the category of “AML, not otherwise specified” in the WHO 2016 classification of hematopoietic ...

Acute fibrinous and organizing pneumonia (AFOP) is an entity that can be secondary to various conditions leading to lung injury, such as infections, malignancies, and various autoimmune conditions or ...