but we are reprogramming a normal cell to transform it into a pacemaker cell," said Eugenio Cingolani, MD, director of the Cardiogenetics-Familial Arrhythmia Clinic at Cedars Sinai Medical Center ...

The current dogma about the heartbeat origin is based on “the pacemaker cell,” a specialized cell residing in the sinoatrial node (SAN) that exhibits spontaneous diastolic depolarization triggering ...

Biological pacemaker is a therapy for cardiac rhythm disease, which can be transformed from ventricular myocytes (VMs) by overexpressing HCN gene which codes the expression of ...

mathrm{f}}$) and knocking off Kir2.1 gene which codes inward-rectifier potassium current (${\mathrm {I}}_{\mathrm{K1}}$). Our previous study built a biological pacemaker single cell model and ...

Studies in animal models have revealed that pacemaker cells share a common progenitor with the (pro)epicardium, and that the pacemaker cardiomyocytes further diversify into ‘transitional’, ‘tail’, and ...

The SARS-CoV-2 virus can infect pacemaker cells that regulate the heart’s rhythm, triggering a self-destruction process. This may explain the heart arrhythmias often seen in SARS-CoV-2 patients. Are ...

A New York-based team of researchers explored the impact of SARS-CoV-2 infection on the pacemaker cells of the heart. To do this, they used both a hamster model and human embryonic stem cell (ESC ...

The SARS-CoV-2 virus can infect specialized pacemaker cells that maintain the heart's rhythmic beat, setting off a self-destruction process within the cells, according to a preclinical study.

Third, it is unknown whether the SAN damage caused by SARS-CoV-2 is reversible. If the viral infection leads to ferroptosis and eventually cell death in SAN pacemaker cells, the SAN damage is likely ...

In this study, using both a hamster model and human embryonic stem cell–SAN–like pacemaker cells, the impact of SARS-CoV-2 infection on the primary pacemaker cells of the heart was explored.

Implantable pacemaker. Most pacemakers pace the atria, or upper chambers of the heart. This is because, traditionally, the pacemaker cells start in the atria.