The failure of cell proliferation to be properly regulated is a hallmark of tumourigenesis. The retinoblastoma protein (pRb) pathway represents a key component in the regulation of the cell cycle ...

Figure 1: Expression of pRb and p16 as a function of cell density. Figure 3: hTERT clones undergo normal growth arrest in response to PALA and γ-irradiation. Figure 4: hTERT clones arrest ...