Human papillomavirus (HPV) can drive tumor development in some rare sinonasal squamous cell carcinomas (SNSCCs), according to ...

Dr. Mabel Mardones educates patients on breast cancer subtypes, as well as treatment options for those with ER-positive, HER2 ...

这篇研究揭示了体细胞PIK3CA和MAP3K3突变在散发性脑脊髓海绵状血管畸形（CMs）中的临床意义。通过分析50例手术患者的突变数据，发现PIK3CA突变（如E542K、E545K、H1047R）与发育性静脉异常（DVA）相关，且是早期再出血的独立风险因子；而MAP3K3 I441M突变多见于Zabramski ...

Envision this possible future clinical scenario: a breast cancer patient and her physicians are deciding on the best possible treatment. Their decision is informed by a comprehensive molecular profile ...

2025年6月3日，一项名为INAVO120的3期双盲、随机临床试验结果“Overall Survival with Inavolisib in PIK3CA -Mutated Advanced Breast Cancer”在New England Journal of Medicine ...

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We thank the Heflin Genomics Institute at UAB, UAB fish facility staff, the University of Massachusetts Chan Medical School (UMass Chan) fish facility, the Research Computing teams at the University ...

In their labs, the scientists have introduced a gene mutation that causes female mosquito offspring to hatch without functional ovaries, rendering them infertile. Male mosquito offspring can carry ...

Mutations in the PIK3CA gene are a key driver of breast cancer and are present in 35–40% of hormone receptor–positive breast cancers. A recently completed phase 3 clinical trial, conducted by ...