BMPER attenuated PI3K/AKT signaling and suppressed BMP4-driven smooth muscle activation in models of PAH. BMPER overexpression mitigated the vascular remodeling that characterizes pulmonary arterial ...

Investigating tirzepatide's role in Alzheimer's reveals its potential to improve brain function and reduce inflammation, ...

A new AI-driven multimodal fusion system accurately predicts survival outcomes in patients with unresectable liver cancer ...

The FDA approved taletrectinib for ROS1-positive NSCLC. The agent shows efficacy for both new and pretreated cases, including ...

From the Department of Pharmacology (K.A.O., X.D.) and Department of Biochemistry and Molecular Biology (N.H.), University of Illinois at Chicago, Chicago, IL; and ...

本研究针对乳腺癌高发病率与转移难题，揭示了γ-谷氨酰环化转移酶（GGCT）在调控乳腺癌细胞增殖、迁移和侵袭中的关键作用 ...

前列腺癌（PCa）是全球高发恶性肿瘤，但现有筛查和治疗手段存在局限。为解决NEIL3在前列腺癌中的作用机制问题，河北大学 ...

RNA-Seq showed upregulation of critical genes in the PI3K-Akt signaling pathway (Egfr, Pik3c, Akt3), linked to cell proliferation and survival. IHC confirmed increased expression of EGFR, AKT, PIK3, ...