Netherlands Activation of the phosphatidylinositol-3-kinase (PI3-K)/protein kinase B (AKT) pathway is associated with three major radioresistance mechanisms: intrinsic radioresistance; tumour-cell ...

In an era dominated by pricey, high-tech drugs, the humble aspirin had a practice-changing impact on colorectal cancer (CRC) ...

A few years earlier I'd helped show that a phosphatidylinositol (PI) kinase activity copurified with various oncoprotein tyrosine kinases, and that this association was critical for the ability of ...

The goal of my laboratory is to understand the regulatory relationship between cellular signaling pathways and metabolic pathways. We are particularly interested in the PI3K (phosphoinositide-3-kinase ...

These data suggest PI3 kinase/mTOR signalling is an important component in TGF-β 1 induced αSMA and collagen gene expression and that an mTOR dependent, Akt independent pathway mediates this ...

The laboratory is studying small molecules that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K ... RAF kinase-driven ERK activation. The combination of Hsp90 inhibitors with RAF or MEK ...

Netherlands Activation of the phosphatidylinositol-3-kinase (PI3-K)/protein kinase B (AKT) pathway is associated with three major radioresistance mechanisms: intrinsic radioresistance; tumour-cell ...

"Aspirin 160 mg reduced recurrence by more than 50% in colorectal cancer patients with tumors harboring mutations in the PI3 kinase pathway," said Martling. "This is the first trial to show that ...