Pancreatic cancer is predicted to become the second-deadliest cancer in the US by 2030. Researchers at the Cold Spring Harbor Laboratory have found a way to slow the progression of pancreatic ...

This fundamental research conducted a molecular comparison between smooth muscle cells and adjacent fibroblast cells within lung blood vessels affected by ... D) Immunoflourescent and in situ ...

研究结果：通过基因本体（GO）富集分析发现，PDGFRA hi PDGFRB lo 星状细胞表现出更高的细胞外基质重塑表型，并能够分泌更多的胶原蛋白。多重免疫 ...

Get Instant Summarized Text (Gist) A new method identifies and classifies pancreatic cancer cell subtypes using glycan signatures on cell surfaces. This technique, multiplexed glycan ...

Targeted new approach to treat pancreatic cancer Scientists transform genetic culprit behind treatment resistance into a skillful tool to use against cancer Date: April 8, 2025 Source: City of ...

Researchers at City of Hope have identified a new molecular target for treating pancreatic cancer and reported on a series of preclinical studies and the first clinical evidence indicating the ...

Pancreatic cancer is frequently a lethal disease with an aggressive tumour biology often presenting with non-specific symptoms. Median survival is approximately 4 months with a 5-year survival of 13%.

Pigment epithelium-derived factor (PEDF), a major antiangiogenic factor, is abundantly secreted by SSc fibroblasts. Here, we investigated the effect of TGF-β and Cav-1 on PEDF expression and the role ...

为探究多发性硬化（MS）脱髓鞘发病机制及早期干预策略，研究人员通过诱导 Pdgfra CreER;Apc fl/fl 和 Olig2 Cre;Apc fl/fl 小鼠实验性自身免疫性脑脊髓炎（EAE）建模研究。结果发现 OPC 调控的免疫细胞网络促早期脱髓鞘，为 MS 病理生理研究及早期干预提供思路。

小儿高级别胶质瘤，尤其是H3K27M弥漫性中线胶质瘤（DMG），是侵袭性恶性脑肿瘤，预后较差。先前的研究表明，血小板衍生生长因子受体α (PDGFRA)似乎在成人和儿童高级别胶质瘤的发病机制中起着多方面的作用。PDGFRA的基因改变不仅在儿童高级别胶质瘤患者中很 ...