为探究精神疾病中神经元细胞的病理机制，研究人员以精神分裂症（SZ）等精神病患者为对象，研究 p62 在其中的作用。结果发现患者嗅神经元细胞（ONCs）中 p62 蛋白上调，且其表达模式与健康人不同。该研究为理解精神病发病机制提供新视角。

Usutu 病毒（USUV）严重影响鸟类和人类健康。为探究其与宿主细胞的相互作用机制，研究人员开展了关于 USUV NS4A 蛋白的研究。结果发现，USUV NS4A 诱导自噬，且被 p62/SQSTM1 靶向降解，这揭示了宿主抗病毒防御的新机制，为防控 USUV 感染提供新方向。

PCD involves multiple aspects and conditions, including immunity, cancer and infection (Nguyen et al., 2023). PCD comprises ferroptosis, apoptosis, autophagy, pyroptosis, and the recently uncovered ...

Interferon-induced ADPr colocalizes with PARP14 and its associated E3 ligase, DTX3L. These PARP14/ADPr condensates contain key components of p62 bodies—including the selective autophagy receptor p62, ...

The occurrence of autophagy was observed by TEM (Tansmission electron microscopy ... The primary antibodies AMPK, p-AMPKa (Thr172), ULK1, p-ULK1 (Ser555), S6K, p-S6K (Thr389), mTOR, p-mTOR (Ser2448), ...

Now, there’s a new study that suggests that cold plunging can literally impact you on a cellular level, triggering them to start a process called autophagy that can have total-body benefits.

The tagged junk and p62 are then both broken down by autophagy. The accumulation of this protein suggests that autophagy wasn’t working properly. Elevated p62 levels were seen alongside a rise ...

COTABATO CITY — Sixteen Bangsamoro lawmakers provided hospitals and rural health units (RHUs) in the autonomous region with P62.1 million worth of financial support, ambulances and other ...

While fasting is primarily a spiritual discipline, modern scientific research highlights its remarkable health benefits, particularly through a process known as Autophagy. The term autophagy, derived ...