Biogen Inc. has disclosed uracil nucleotide/cysteinyl leukotriene receptor (GPR17; P2Y-Like) antagonists with improved brain penetration reported to be useful for the treatment of multiple sclerosis.

此前的研究虽发现 COVID-19 与广泛的炎症变化有关，且小胶质细胞（中枢神经系统实质中的主要炎症细胞）在患者大脑中出现形态转变和炎症特征，但 SARS-CoV-2 感染、中枢神经系统炎症和小胶质细胞表型变化之间的具体联系却尚不明确。正是在这样的背景下，研究人员开展了此次意义重大的研究，试图揭开 COVID-19 相关神经异常机制的神秘面纱。

Bentracimab is an investigational human monoclonal antibody fragment that binds to ticagrelor, an oral P2Y 12 platelet inhibitor, reversing its antiplatelet effects. The BLA submission is supported by ...

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