为解决实时活细胞 DNA 可视化难题，研究人员开展了利用 Oligo-LiveFISH 动态追踪非重复基因组位点的研究。该技术实现 20nm 空间和 50ms 时间分辨率的染色质成像，揭示染色质通讯模式，对研究 3D 基因组动力学意义重大。

为解决寡核苷酸药物穿越血脑屏障（bbb）及快速降低毒性蛋白的挑战，研究人员开发脑穿透性 dna 纳米花结合寡核苷酸靶向蛋白降解嵌合体（oligo-protac）。以 fus 为模型，证实其通过泛素 - 蛋白酶体通路降解 fus，单次静脉注射可穿透 bbb 并持续降靶，为神经退行性疾病治疗提供新策略。

Oligo 768XLc ，这是用于 ... Biolytic Introduces the Dr. Oligo 768XLc DNA RNA Synthesizer - Synthesizing 768 Oligos Just Got Faster (Photo: Business Wire) April 15, 2020 04:45 AM Eastern ...

There are plenty of companies making everything from short DNA fragments (called “oligos”) ... Phosphoramidite chemistry, developed in the 1980s, is the standard method for DNA oligo synthesis.

Please use one of the following formats to cite this article in your essay, paper or report: APA. Mandal, Ananya. (2023, July 20). What is an Oligonucleotide?.

This "muscle-forming oligo DNA" (myoDN) has potential for use in nucleic acid drugs for various muscle diseases. In this study, the group examined whether myoDN improves the differentiation of ...

A new platform for making oligonucleotides offers chemists a way to plug in five types of nucleoside connections, so they can tailor properties of oligonucleotide therapeutics. These short DNA or ...

The gold standard for DNA writing, phosphoramidite chemistry, works incredibly well on short, uncomplicated, oligos. For longer stretches of DNA, which may contain DNA with complex features such ...