How alterations in cell metabolism translate into specific developmental gene programs remains a major question. This study ...

Hantavirus, which is rare, shot to public attention after a New Mexico medical examiner announced that Gene Hackman’s wife Betsy Arakawa had died after contracting the virus. The bodies of ...

这篇综述系统阐述了生发中心B细胞(GCBCs)独特的代谢重编程现象：不同于其他快速增殖的免疫细胞，GCBCs主要依赖脂肪酸氧化(FAO)和氧化磷酸化(OxPhos)供能，而非糖酵解；同时将葡萄糖和氨基酸优先用于生物合成途径。文章通过最新小鼠模型揭示了GCBC代谢与亲和力 ...

A team of researchers has uncovered a previously unrecognized role of mitochondrial protein synthesis in the maintenance of intracellular iron distribution. Disruption of this process was found to ...

While MTO1 has been identified as vital for survival, mutations in the MTO1 gene have previously been linked to severe anemia ... discovering that the formation of mitochondrial oxidative ...

the team generated a mouse model in which the MTO1 gene was knocked out exclusively in hematopoietic cells. These mice all died before birth, and their fetal development was marked by severe anemia.

Using its gene-editing technology on dire wolves was a smart decision, according to Greely. For one thing, a wolf’s gestation period is just over two months, whereas that of an Asian elephant ...

Dire wolf pups born using gene-edited ancient DNA CRISPR used to match dire wolf genes in grey wolf embryos Dallas firm Colossal leads species restoration breakthrough ...

It is known as an important enzyme indispensable for survival, and mutations in MTO1 gene have been associated ... causes hematological disorders. The OXPHOS complexes normally incorporate various ...

By inserting an entire gene, the tool offers a one-and-done approach that overcomes hurdles from CRISPR gene editing technology—which is programmed to correct individual mutations—offering a ...

Mitochondria are the powerhouses of our cells, responsible for generating most cellular ATP through the oxidative phosphorylation (OXPHOS) pathway. In addition to providing cellular ATP, mitochondria ...