The Faculty Development Grant Program, or FDGP, provides seed money for research, scholarship and creative activities in a ...

André Briend is the 2025 recipient of the John Dirks Canada Gairdner Global Health Award, which recognizes outstanding ...

PRNewswire/ - The Gairdner Foundation is pleased to announce the 2025 Canada Gairdner Award laureates, recognizing some o ...

In a mouse study, they describe a brain pathway that starts with neurons (labeled in green, above) that sense inflammation signals, and the researchers were able to treat the loss of motivation by ...

Folic acid controls neurogenesis and gliogenesis by triggering the Notch1 signaling pathway in embryonic neuronal stem cells (NSCs). Multiple studies have shown that the Notch signaling pathway is ...

CD47-amyloid-β-CD74 signaling is a key driver of adaptive immunosuppression in sepsis, suppressing B cells and impairing immunity. Blocking this pathway restores immune function and improves survival ...

For this article, Eugene Russo interviewed Mark E. Fortini, an assistant professor of genetics at the University of Pennsylvania, Iva Greenwald, a Howard Hughes Medical Institute investigator and ...

James is a published author with four pop-history and science books to his name. He specializes in history, strange science, and anything out of the ordinary.

They must then overcome the blood-brain barrier (BBB) to establish and grow in the brain. Multiple signaling pathways, including PI3K/AKT, STAT3, NF-κB, Notch, and Wnt are involved in this process.

Noncanonical signaling involves interactions with other pathways without RBPJ involvement. The NOTCH pathway contributes to resistance by regulating cell survival, apoptosis, and the tumor ...

Canonical signaling involves the cleavage of NOTCH receptors and the subsequent activation of target genes through the NICD-RBPJ complex. Noncanonical signaling involves interactions with other ...