Nitric oxide (NO) is a gaseous signalling molecule that is involved in the regulation of the cardiovascular, immune and nervous systems. In the CNS, NO is involved in many processes, including the ...

S-nitrosylation was primarily discovered by Japanese scientists in 1983. S-nitrosylation is characterized by the covalent attachment of nitric oxide (NO) or its derivatives to the thiol groups of ...

Nitric oxide (NO) is a small free radical generated by a family of enzymes, the nitric oxide synthases (NOSs). Following injury to a tendon, NO is induced by all three isoforms of NOS and NOS activity ...

为探究线粒体对 T 细胞功能及免疫治疗反应的调控机制，研究人员开展了丙酮酸激酶 M2（PKM2）激活影响 CD8 和嵌合抗原受体（CAR）-T 细胞的研究。结果发现 PKM2 激活增强线粒体功能，提升抗肿瘤活性，还能增强抗 PD1 疗法效果，有望成为临床免疫治疗新策略。

为探究丙酮酸激酶 M2（PKM2）巴豆酰化在血管平滑肌细胞（VSMC）表型转换中的作用，研究人员开展了相关研究。结果发现 PKM2 K305 巴豆酰化可促进 VSMC 有氧糖酵解和表型转换，这为深入理解相关生理病理过程提供了新视角。 丙酮酸激酶 M2（PKM2）的翻译后修饰（PTMs ...

School of Chemical Sciences, Indian Association for the Cultivation of Science, 2A & 2B Raja S. C. Mullick Road, Kolkata 700032, West Bengal, India ...

This study aimed to investigate the effect of circ_0098181 in fibrogenesis and explore its mechanism. Conclusion: In conclusion, circ_0098181 exerts a significant anti-fibrotic effect by binding PKM2 ...

OXFORD, Miss. – Despite a recent Food and Drug Administration warning against inhaling nitrous oxide, commonly known as laughing gas, deaths due to misusing the substance are rising in the United ...

explore whether its nitric oxide pathway manipulation actually produces measurable results, and break down how it compares to prescription treatments and shady knockoffs flooding Amazon and eBay ...

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Nitrate is also available as a variety of dietary supplements. The body needs nitrate to produce nitric oxide (NO), a signaling molecule involved in regulating hormones and blood flow to tissues in ...