药物性肝损伤（DILI）是西方国家急性肝衰竭（ALF）和肝移植的重要原因。对乙酰氨基酚（APAP）过量是DILI的主要促成因素，导致肝细胞通过坏死死亡，该研究旨在探究Neddylation在DILI在，尤其是APAP过量引起的肝损伤中的作用和机制。

Aromatase is an enzyme that converts testosterone to estradiol, a type of estrogen. One study found that taking an estrogen blocker called an aromatase inhibitor while on testosterone therapy reduced ...

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micro-RNA-mediated inhibition of p27 translation emerges as a novel mechanism that can reduce p27 in some human cancers. p27 proteolysis is initiated by several different mechanisms. Tyrosine (Tyr ...

Inhibition of PI3Kγ alone is ineffective in PDAC, despite increased infiltration of CD8+ T cells. Objective We hypothesised that the immune stimulatory effects of radiation, and its ability to boost ...

State Key Laboratory of Fine Chemicals, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518055, China ...

Small GTPase RHEB is a well-known mTORC1 activator, whereas neddylation modifies cullins and non-cullin substrates to regulate their activity, subcellular localization and stability. Whether and how ...

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China Department of Medicinal Chemistry, School ...

“Our STAT6 program represents a significant advancement in the discovery of an oral inhibitor for type 2 inflammatory diseases to overcome the limitations seen with marketed injectable therapies ...