Researchers have developed a machine learning model that predicts Cas9 proteins that can be tailored with designer properties for therapeutic use.

Most cells in the human body each contain about six feet of DNA. Yet the nucleus, where DNA is coiled, is no larger than a ...

Learn about Brink Therapeutics as it raises $4 million to go beyond CRISPR with engineered recombinases in CAR T therapy.

他们的研究成果发表在《Nature Methods》上，为 3D 基因组的研究开辟了新的道路。 研究人员开发了一种基于图像的高通量高内涵筛选平台 ——Perturb-tracing。该平台主要运用了三个关键技术：一是汇集式 CRISPR 筛选（pooled CRISPR screens），能够对众多候选基因进行大 ...

began with a genome-wide genetic screen based on CRISPR interference (CRISPRi) that systemically reduces the expression of every single gene in the genome of a pluripotent stem cell (PSC ...

Its simplicity has facilitated large-scale experiments to assess gene functionality across diverse biological contexts, generating extensive datasets that boosted the development of computational ...

Algorithm transfer is a key prerequisite for the development of a commercial wearable non-invasive glucose monitor for universal use Study based on the participation of 50 people with type 2 ...

Dr. Guido Freckmann, Medical Director & CEO of the Institute for Diabetes Technology (IfDT), Ulm, and one of the co-authors of the Nature study said: "The published study had a robust design and ...

However, even this LRA combination needs improvement as it is inefficient at activating proviruses in cells of people living with HIV (PLWH). We performed a CRISPR screen in conjunction with AZD5582 & ...

研究结果表明，CAVE 是一个强大的计算基础设施，为大规模数据集的校对和注释提供了可扩展的解决方案，能够实现任意时间点的快速分析查询，这一成果发表在《Nature Methods》上。 为开展此项研究，研究人员运用了多种关键技术方法。在数据存储和处理方面 ...