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阿司匹林启发的6-O-羧甲基-N-乙酰葡糖胺 (CM-NAG):一种 ...
阿司匹林虽展现抗癌潜力,但其严重副作用限制了临床应用。受其启发设计的6-O-羧甲基-N-乙酰葡糖胺 (CM-NAG)展现出更优异的抗肿瘤特性:在结直肠癌和胰腺癌细胞中,CM-NAG不仅强力抑制细胞存活,还显著阻断肿瘤转移侵袭,并高效诱导细胞凋亡。机制研究发现,CM-NAG能激活糖异生关键酶——磷酸 ...
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