Announcement follows FDA's February 2025 decision to grantradiprodil Breakthrough Therapy designation Company remains on track to initiate Phase 3 pivotal trial ofradiprodil ...

The G-protein coupled receptor family of glutamate receptors, termed metabotropic glutamate receptors (mGluRs), are implicated in numerous cellular mechanisms ranging from neural development to the ...

aNew York University, School of Medicine, Department of Psychiatry, New York, NY, USA bNew York University, School of Medicine, Center for Cognitive Neurology, Department of Neurology, New York, NY, ...

potent negative allosteric modulator selectively targeting the N-methyl-D-aspartate receptor subtype 2B (NR2B or GluN2B), for the treatment of seizures associated with GRIN-related ...

Nuclear receptors regulate transcription in response to ligand signals and enable the pharmacological control of gene expression. However, many nuclear receptors are still poorly explored and are not ...

其作用机制独特，能对多巴胺D1和D2受体发挥部分激动作用，同时拮抗5-HT2A受体，抑制DA和5-HT转运体，还能促进NMDA受体的NR2B亚基活化。体外研究数据 ...

New neurons are continuously generated from stem cells and integrated into the adult hippocampal circuitry, contributing to memory function. Several environmental, cellular, and molecular factors ...