Antiretroviral therapy (ART) initiated in the acute phase of HIV infection (AHI) results in a smaller viral reservoir. However, the impact of early HIV-specific T-cell responses on long-term reservoir ...

Innate lymphoid cells, which curiously behave like T cells even though they don’t recognize specific antigens, show promise as a potential cancer therapeutic.

We found that stimulated B and NK cells had an increased proportion of free compared to protein-bound NAD(P)H, a reduced redox state, and produced more lactate compared to control cells. The NAD(P)H ...

The EuTDA assay uses time-resolved fluorometry (TRF) and the measured fluorescence signal correlates directly with the amount of lysed cells (PerkinElmer Inc., Boston, MA, USA). TCR-NK-92 cells ...

While NK cell therapies can potentially avoid the serious side effects sometimes seen with CAR T cell therapies, experts say durability may stall their path to the market. When the first CAR T cell ...

NK cells have been observed to be present within most solid tumors, but the antitumor activity of the intratumoral NK cells has been unclear. In this study, we examined the entire spectrum of innate ...

E. mRNA levels of selected PGE 2 response elements as measured by qPCR in NK cells (n = 3–4, biological replicates). F. Fold change comparing flow cytometry mean fluorescence intensity (MFI) values of ...

Mean fluorescence intensity was adjusted to relative fluorescent intensity by normalizing to the WT condition. FACS analysis of WT or CD56-KO NK92 and YTS cell lines was performed using modified NK ...