All computer algorithms are based on 3D structures that do not correlate with the active structure of any 3D protein. Professor Niazi created a new paradox: "3D structure is based on but ...

A mutated gene results in the loss of neurofibromin, which allows cells to grow uncontrollably. The NF2 gene is located on chromosome 22, and produces a protein called merlin (also called schwannomin) ...

The NF2 gene encodes the production of a protein called merlin, which can clump together around nerve cells to form benign tumors. NF2 is a relatively uncommon condition, affecting roughly one of ...

Scientists have for the first time looked deep into the protein structure that may determine ... Moreover, mutations in the gene encoding RBP3 are associated with several eye diseases, including ...

Department of Otorhinolaryngology- Head and Neck Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, Republic of Korea ...

That workaround often involves RAD52 — a protein now squarely in the sights of researchers hunting for new anti-cancer drugs. A new study published in Nature reveals an unexpected structure ...

MULAN uses the pre-trained base PLM and has the Structure Adapter – a module we introduce to incorporate the knowledge about the 3D protein structure. Our model uses ESM-2 architecture, initializing ...

College of Food Science and Engineering, Shandong Agricultural University, Tai’an, Shandong 271018, China Engineering and Technology Center for Grain Processing in Shandong Province, Tai’an, Shandong ...

When glucose binds to IRF6, it causes the protein to change its conformation in a way that changes its ability to influence gene expression and drive differentiation. “We’re seeing glucose ...

“Our structure reveals many new ways to change ... contain hundreds or thousands of mitochondria. The PARK6 gene encodes the PINK1 protein, which supports cell survival by detecting damaged ...

we describe the 1.9 Å resolution structure of E. coli FhuD in complex with gallichrome. FhuD adopts a novel fold and represents a new class of iron binding ABC-type transport proteins.