Experiment and modeling were combined to understand inhibition of the alanine-serine-cysteine-1 (asc1) transporter. The structure–activity relationship (SAR) was explored with synthesis of analogues ...

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The war in Ukraine has brought Russia and Nato closer to conflict than ever before. Although Ukraine is not a Nato member, if Moscow were to attack one of Ukraine's allies that is, then all other ...

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Cysteine-elimination-induced browning and weight loss requires noradrenergic signaling. a, Tissue clearing and whole-brain c-Fos immunolabelling approach. b, Scheme of the thermosensory ...

We then analyzed the biomarkers of cysteine metabolism and cell death pathways in tumor samples of different treatment groups . Erastin and cysteine deprivation monotherapy, or combined with ...

Cysteine amides react with MG and LGSH to generate Lac-Cys or lactate in GLO1 and 2 like reactions. Credit: Nature Chemical Biology (2025). DOI: 10.1038/s41589-025-01909-0 ...

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A covalent NOS bond forms between lysine and cysteine residues in proteins under oxidizing conditions, with an oxygen atom linking the two. This bond, distinct from disulfide bonds, ...