In 2021, research led by Ryan Flynn, MD, PhD, and his mentor, Nobel laureate Carolyn Bertozzi, PhD, opened a new chapter in biology, characterizing a new kind of player on the cell surface: glycoRNAs.

This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma, mediated via SHP-1 activation and antibody clustering, independent of ...

A new study published in the Journal of Affective Disorders has identified a two-way relationship between ...

Researchers have developed drug-delivering aptamers that can deliver a cytotoxic double punch to leukemic stem cells.

"In vitro-derived HSPCs exhibit cell-surface markers similar to those of their ... HSPC generation in vitro and leads to improved myeloid chimerism in immuncompromised mice. These findings suggest ...

From the Department of Cardiology and Angiology I, University Heart Center Freiburg, Germany (D.W.) Faculty of Medicine, University of Freiburg, Germany (D.W.) K. Ley has received research funding for ...

"It's important in leukemia, lymphoma or other blood cancers that we actually target and eliminate these stem cells, because as long as any are remaining, they can cause relapse and secondary cancers, ...

We found that the transcriptional changes associated with the transition from basal to luminal fate are progressive in time, triggered by the initial decrease in basal markers expression followed by ...

"It's important in leukemia, lymphoma or other blood cancers that we actually target and eliminate these stem cells, because as long as any are remaining, they can cause relapse and secondary cancers, ...

The researchers began by finding DNA aptamers that seek out markers found on the surface of acute myeloid leukemia stem cells. They wanted to target not just the cancer, but the stem cells ...