In the periphery, muscarinic acetylcholine receptors mediate cholinergic signals to autonomic organs, but specific physiological functions of each subtype remain poorly elucidated. Here, we have ...

Muscarinic receptor (mAChR) transmission modulates intrinsic excitability and allows for ... Neuronal activity is shaped by both synaptic transmission and intrinsic excitability. Changes in either of ...

Thus, G-protein-coupled receptors can regulate NMDA receptor function indirectly through a PKC-dependent activation of the non-receptor tyrosine kinase (Src) signaling cascade. You have full ...

† Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, Kentucky 40536, United States ‡ Department of Pharmaceutical Sciences, ...

"This compound is promising as it is a direct and selective muscarinic M4 receptor agonist, which is believed to be a key regulator of neurotransmitters impacted by schizophrenia, and we look ...

Williams, W. R. (2025) Nucleotide Relative Molecular Similarity within Anti-Psychotic Drug Structures. Journal of Biosciences and Medicines, 13, 106-117. doi: 10.4236/jbm.2025.136010 .

Department of Pharmacology & Toxicology, R. Ken Coit College of Pharmacy, University of Arizona, Tucson, Arizona 85721, United States ...

Thermal receptors called ionotropic receptors (IRs), specifically IR25a and IR21a, function in cool temperature-sensing neurons in larval heads known as dorsal organ cool cells (DOCCs), to mediate ...

2011;9(12):1565-1584. The effector face, at the opposite side of the CRP pentamer, recognizes the complement pathway component (C1q) and cell surface Fcγ receptors (FcγRs). [14] It carries a ...