The multivesicular-body (MVB) sorting pathway delivers transmembrane proteins and lipids into small vesicles that invaginate into the lumen of the endosome. MVBs fuse with the vacuole/lysosome and ...

Zhao, GN., Zhang, P., Gong, J. et al. Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation ...

They are generally understood as having been released from cells upon fusion with an intermediate endocytic compartment, or a multivesicular body (MVB). Credit: dreamerb/Shutterstock.com ...

Intraluminal vesicles are essentially the precursors of exosomes, and form by budding into the lumen of the multivesicular body. Most intraluminal vesicles fuse with lysosomes for subsequent ...