Heatmap indicates the mean PPID predicted by Giri et al. (2021) and experimental methods used to characterize SARS-CoV-2 proteins structure. The mean PPID of the all protein except Nsp11 is taken from ...

Self-assembled peptides are promising templates for the design of inhibitors of protein–protein interactions (PPIs) because they can be endowed with affinity- and selectivity-defining amino acids ...

The cellular environment is crowded with high concentrations of macromolecules that significantly reduce accessible volume for biomolecular interactions. Reductions in cellular volume can generate ...

Get Instant Summarized Text (Gist) Sequencing of enamel proteins from four Paranthropus robustus teeth, dated to 1.8–2.2 million years ago, enabled identification of biological sex and revealed ...

Protein-protein interactions (PPIs) play a crucial role in cellular biochemical reactions. Computationally mining PPI can help us better understand cellular regulatory mechanisms. Most existing ...

Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency. Alexander Leithner https: ... , which allow for the comparison of the shape and flexibility of ...

In addition to the GSH defense system, radical trapping antioxidants (RTAs) also promote ferroptosis resistance (1, 3, 11).The FAD-dependent oxidoreductase ferroptosis suppressor protein 1 (FSP1) ...

A proteomics-driven 24-protein classifier improves the differentiation of thyroid adenoma and carcinoma, retrospectively and prospectively validated across multi-center cohorts, with up to 95.7% ne ...

Researchers from the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) have uncovered the 3D structure of the membrane proteins myoferlin and dysferlin using high-resolution cryo ...

Watson JL, Juergens D, Bennett NR, et al. De novo design of protein structure and function with RFdiffusion. Nature 2023;620:1089-1100. Crossref. PubMed. Web of Science. Google Scholar.