For subsequent diagnosis and possible treatment, it is essential to understand mechanisms of DEE development. The important part of developmental studies is the creation of animal models. In this ...

Through multiple whole-cell patch-clamp recordings after the sequential in utero electroporation, we discovered that the combinatorial expression ... combinatorial expression of γ-PCDHs of neurons in ...

Dual in utero electroporation provides a precise and effective tool to label and manipulate ... Combine reagents so that there is a total of 10 µL plasmid DNA per mouse. DNA dilution can range from 1 ...

In new research, scientists grew mouse embryos to half term in an artificial womb. The milestone is equivalent to a human embryo at five weeks development. Early pregnancy and implantation are ...

By Gina Kolata The mouse embryos looked perfectly normal ... should or could be cultured outside a living womb. In a study published in the journal Nature, Dr. Jacob Hanna described removing ...

Researchers are growing embryos outside the womb for longer than has ever been possible. The photographs alone tell a fantastic story—a mouse embryo, complete with beating heart cells ...

In utero exposure to maternal immune activation (MIA) is an environmental risk factor for neurodevelopmental and neuropsychiatric disorders. Animal models provide an opportunity to identify mechanisms ...

Companies that hope to treat severe inherited diseases via CRISPR genome editing are already testing the technique in adults, while push-the-envelope types are arguing for repairing defective ...

To examine the role of the PDK1–Akt pathway in neuronal migration, we have now determined the effects of conditional ablation of the PDK1 gene (Pdpk1) or inhibition of Akt with the use of in utero ...

Nrp2-Δ mouse brain. No significant difference in migration was observed. Ctx, cortex; GE, ganglionic eminence. (Scale bars, 200 µm.) Fig. S11. Nrp1 overexpression shows almost the identical effect ...