"By means of genetic capturing, activity manipulation and single-cell RNA sequencing, we identified distinct neural ensembles in the adult mouse spinal cord encoding mechanical and heat pain." ...

meaning their spinal cord was cut off from their brains. One mouse was designated as the "control," the other "experimental." Both were then dangled from a harness. When the experimental mouse's ...

This image shows cerebrospinal fluid-contacting neurons genetically labeled with a fluorescent green marker, along the length of a mouse spinal cord. These neurons are found in the ependymal layer ...

In trials on living mice, the combination of implanted microprism and wearable microscope was able to image astrocytes, glial cells in the spinal cord involved in pain processing, and follow their ...

To create the mouse model, Kelani induced spinal cord hypoperfusion and ISCI in adult mice by ligating (or "tying") five pairs of the arteries branching off from the aorta (known as intercostal ...

It ultimately yielded views of more than 30,000 neurons spread across a 3-millimeter span of spinal cord of each mouse. Cells called inhibitory neurons, which dampen other cells’ activity ...

Partial damage of human and mouse spinal cords can cause initial paralysis, but spontaneous recovery of motor function most often follows. This is not true of a complete spinal cord injury.

In 2023, the NeuroRestore team was able to make a fully paralyzed mouse walk by regenerating the nerves in its spinal cord. There are many hurdles before that kind of gene therapy, typically ...