Metallothionein (MT) crypt-restricted immunopositivity indices (MTCRII) are colonic crypt stem cell mutation markers that may be induced early and in abundance after mutagen treatment.

Oncogenesis - Suppression of radiation-induced DNA double-strand break repair by MyD88 is accompanied by apoptosis and crypt loss in mouse colon Skip to main content Thank you for visiting nature.com.

The intestines and colon are normally lined with a single layer of cells to absorb nutrients from food. There are regular small pockets in the intestines called crypts, where stem cells are gathered.

Each crypt is only about 75 to 110 cells deep and 23 cells in circumference, and the human colon has about 9,950,000 crypts. ... Mice with loss of IL-22 production only in the T cells began to succumb ...

They measured the survival of colon crypts in the small and large intestines in normal and mutant mice following radiation exposure, looking at the responses to both single doses of radiation and ...

Epithelial MHCII is required for mucosal retention of Cr-specific TH cells, prolonged colonocyte STAT3 activation and crypt protection. Credit: Nature (2024). DOI: 10.1038/s41586-024-07288-1 ...

It induces apoptosis at the top of colon crypts 24-26 and has been shown to be effective in primary prevention of colon cancer in animal models 25,27-29 and in combination with other agents in ...

Photography: Jennifer Alsabrook-Turner C. rodentium attaches to the mid-distal region of the mouse colon, initiating a rapid elongation of the colonic crypts — a hallmark of the infection — that is ...

In contrast, T cells contributed to colon barrier defense by delivering IL-22 to both crypt IECs and surface IECs as an infection progressed, inducing robust, sustained STAT3 signaling in both IEC ...