In contrast, inheritance of a mutant Apc allele causes much more rapid development of mouse intestinal tumors (3–5), similar to tumor development in familial adenomatous polyposis (FAP) patients who ...

Objective The inner mucus layer in mouse colon normally separates bacteria from the epithelium. Do humans have a similar inner mucus layer and are defects in this mucus layer a common denominator for ...

Cancer, (uncontrolled cell proliferation), has demonstrably high impact on human life: complex feelings and lifestyle changes, caused by malignancy, affect not only patients, but also family and ...

Normal human colon crypt protein extract was resolved by two-dimensional gel electrophoresis using pH 6−11 immobilized pH gradient strips in the first dimension. The optimized isoelectric focusing ...

Pterostilbene (PS), a natural dimethylated analogue of resveratrol, is known to have diverse pharmacologic activities including anticancer, anti-inflammation, antioxidant, apoptosis, antiproliferation ...

The gastrointestinal epithelium constitutes a chemosensory system for microbiota-derived metabolites such as short-chain fatty acids (SCFA). Here, we investigate the spatial distribution of Olfr78, ...

We have modelled the mouse intestinal crypt as a self-organizing system where cell dynamics and cell composition arise from local interactions between single cells and the mesenchyme through ...

Figure 2.Vascular branches and connections in the mouse colon. The vessels were labeled by WGA painting (cyan in A, B, D and green in C) and CD31 immunoreactivity (red).(A) Submucosal vessels ramified ...

The first identified group of intestinal mesenchymal stromal cell in mouse is named as CD34 + mesenchymal cells that located right near the intestinal crypt . This unique group of intestinal ...

Microscopic examination of colon sections showed that mice with intact immune systems had bacterial attachment to surface IECs at days 4 to 9, but no bacterial growth inside the crypts.