Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard-Karls-Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany Tübingen Center for ...

The complement system plays crucial roles in innate immunity and inflammatory responses. The anaphylatoxin C3a mediates pro-inflammatory and chemotactic functions through the G protein-coupled ...

To overcome these limitations, we engineered oncolytic viruses co-expressing neoantigens and neoantigen-binding major histocompatibility complex (MHC) molecules to force ectopic delivery of ...

BLA accepted for Priority Review Finerenone (Bayer) Nonsteroidal mineralocorticoid receptor antagonist Treatment of adult patients with heart failure with mildly reduced or preserved ejection ...

This patent highlight describes a series of novel 2-pyrrolidone derivatives that act as negative allosteric modulators (NAMs) of GluN2B-containing N-methyl-d-aspartic acid receptors (NMDARs). These ...

Emerging evidence indicates that leptin promotes placental and endothelial dysfunction via diverse pathways involving endothelin-1, mineralocorticoid receptor activation, angiogenic peptides, and ...

Limitations include underrepresented Black and indigenous populations and the inability of the trial to assess combination therapy with sodium-glucose cotransporter 2 inhibitors and nonsteroidal ...