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小麦烷基间苯二酚通过miR-34a/SIRT1轴调控肌纤维类型 ...
分子层面发现,ARs能下调"衰老标志物"miR-34a的表达,同时激活长寿蛋白SIRT1信号通路。 这种双重作用如同解开肌肉生长的基因锁——显著上调成肌调节因子MyoD、肌细胞生成素 (MyoG)和慢肌球蛋白重链 (slow-MyHC),同时抑制肌肉生长抑制素 (MSTN)和快肌球蛋白 (fast-MyHC)。
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