Tau is an intrinsically disordered protein (IDP) implicated in Alzheimer’s disease. Recently, tau proteins were discovered to be able to catalyze self-acetylation, which may promote its pathological ...

The deposition of proteins of abnormal conformation is at the origin of a broad range of human age‐related diseases including the devastating neurodegenerative diseases Alzheimer's (AD), Parkinson's ...

The cross-linking of ubiquitinated misfolded proteins is mediated by NBR1, and like p62, is necessary for protein aggregation and inclusion body formation following autophagy inhibition. 130 NBR1 ...

To investigate how cells maintain their proteostasis during cell division, we employed a proteostasis reporter consists of a firefly luciferase mutant prone for protein misfolding and protein ...

Formation of protein aggregates in the nucleus by ER-FlucDM-eGFP was not limited to MCF10A cells. The protein aggregates were also detected in the nucleus when ER-FlucDM-eGFP was expressed in other ...

Protein aggregation is associated with the pathology of many diseases, especially neurodegenerative diseases. A variety of structurally polymorphic aggregates or preaggregates including amyloid ...

MMP-12 enzymatic activity was significantly higher in patients with COPD than in controls (4.11 (1.4–8.0) v 0.14 (0.1–0.2) μg/μl, p = 0.0002). Conclusion: MMP-12 is markedly increased in induced ...

Background: Several matrix metalloproteinases (MMPs) are involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). In mice, MMP-12 plays a crucial role in the development of ...

Recent evidence indicates that diverse neurodegenerative diseases might have a common cause and pathological mechanism — the misfolding, aggregation and accumulation of proteins in the brain ...