Researchers found that peristaltic pump flow mechanically breaks supersaturation to induce amyloid formation by hen egg white lysozyme, a-synuclein, amyloid b 1-40, and b2-microglobulin.

But in just the past year and a half, two anti-amyloid drugs—lecanemab (Leqembi) and donanemab (Kisunla)—that can slow the progression of early Alzheimer’s disease have been approved in the US.

The conformation of the fibril protein differs fundamentally from natively folded lysozyme, demonstrating the need of protein unfolding for the formation of the pathogenic fibril conformation.

Fluorescence spectroscopy and atomic force microscopy have shown that glyco-acridines inhibit amyloid aggregation of lysozyme; the inhibition efficiency characterized by the half-maximal inhibition ...

Structure of hnRNPDL-2 amyloid fibres obtained by cryoEM at 2.5 A resolution. The upper part shows the organisation of the protein with two nucleic acid binding domains in pink and a low ...

Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843, ...

Lysozyme amyloidosis is a hereditary disease, which is characterized by the deposition of lysozyme amyloid fibrils in various internal organs. It is known that lysozyme fibrils show polymorphism and ...

So Landau plans to use the newly acquired structure to design inhibitors of the amyloid as potential antibiotics. Inhibiting formation of the PSMα3 amyloid could provide a way to decrease ...