So Landau plans to use the newly acquired structure to design inhibitors of the amyloid as potential antibiotics. Inhibiting formation of the PSMα3 amyloid could provide a way to decrease ...

The three-dimensional structures of lysozyme (Protein Data Bank code 1LYY ... chains converge into a cross-beta super-secondary structure that has been well characterized by x-ray diffraction ...

Researchers found that peristaltic pump flow mechanically breaks supersaturation to induce amyloid formation by hen egg white lysozyme, a-synuclein, amyloid b 1-40, and b2-microglobulin.

For instance, E. coli can be lysed by utilizing lysozyme to free the contents of the periplasmic space. The main structure of lysozyme is a single polypeptide that contains 129 amino acids.

Structure of hnRNPDL-2 amyloid fibres obtained by cryoEM at 2.5 A resolution. The upper part shows the organisation of the protein with two nucleic acid binding domains in pink and a low ...

To address this, the researchers ran a model amyloid-forming protein, hen egg white lysozyme, through a peristaltic pump similar to those used for dialysis. They then used fluorescence detection ...

Solving the structure of an amyloid protein gives new insight into limb-girdle muscular dystrophy type 3 (LGMD D3) and functional protein aggregation. LGMD D3 is a rare disease characterized by slow ...

For their new study, the scientists investigated the reasons why TAP01_04 was able to target the soluble amyloid beta so specifically, by solving its crystal structure. This revealed that part of ...