Taken together, we showed that knockout of PDK1 indirectly alters the PI3K/PDK1 signaling axis by regulating gene transcription of Lyn, PI3K subunits and phosphoinositide-modifying enzymes.

Rabbit polyclonal antibodies against AKT, pAKT (Ser473), caspase 3 and 9, Cbl, JAK2, pJAK2(Tyr1007/1008), Lyn, pLyn(Tyr396), Hck, and PARP, PI3K p85 STAT5, pSTAT5(Tyr694), were obtained from Cell ...

The discovery of phosphatidylinositol 3-kinase (PI3K) changed the way we view and understand growth-factor signaling. From early on, it became clear that PI3K plays an important role in many ...

The search for alternative treatments led to the finding that the phosphatidylinositol-3-kinase (PI3K) pathway that controls cell metabolism, growth, division, and survival and allows the cells to ...

HOUSTON -- Two-thirds of patients with PI3K-mutant brain metastases responded to the maximum tolerated dose (MTD) of the small-molecule inhibitor paxalisib plus radiation therapy (RT), a small ...

Researchers unveil PI3K enzyme's dual accelerator and brake mechanisms Date: April 24, 2024 Source: Tohoku University Summary: The enzyme PI3K plays a critical role in cell migration. Scientists ...

MEI Pharma and partner Kyowa Kirin have had to abandon plans to file for approval of their PI3K inhibitor zandelisib in B cell lymphoma, after being "discouraged" by the FDA from making the ...

The FDA recently put the spotlight on the concerning side effects of marketed PI3K inhibitors for blood cancers. Similarly, investigators in the U.K. recorded a high level of side effects among ...

Aspirin reduced colorectal cancer recurrence risk by 50% in patients with PIK3CA mutations over three years. Mutations in the PI3K pathway predict aspirin response, broadening its use to more patients ...