At Bitcoin2025 in Las Vegas, Lyn Ulbricht introduces Mothers Against Cruel Sentencing (MACS), a new nonprofit aimed at reforming harsh prison sentences and supporting families affected by America’s ...

The search for alternative treatments led to the finding that the phosphatidylinositol-3-kinase (PI3K) pathway that controls cell metabolism, growth, division, and survival and allows the cells to ...

leniolisib有潜力为活化的肌醇磷脂3-激酶δ综合征（APDS，一种原发性免疫缺陷）治疗带来一款疾病修正靶向疗法。 乳腺癌是一种恶性疾病，每八名女性中就有一人会在一生中患病(12.9%的终生风险)。由于其细胞和分子的异质性，这是至关重要的，以了解驱动乳腺癌 ...

Phosphorylation of CD19 leads to the membrane recruitment of phosphatidylinositol 3-kinase (PI3K) and activation of Akt, which phosphorylates downstream proteins leading to their inhibition [red (P)] ...

From the Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Italy (A.G., M. Li, E.H.); and INSERM U1048 ...

Activating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may ...

Deficiency in Gβγ binding, significantly reduced rates of proliferation while p110β-Lyn RBM supported growth comparable to p110β-Lyn (Figure 5A). Signal transduction via the PI3K pathway requires a ...

目前已被发现能诱导人角质形成细胞和成纤维样滑膜细胞（FLS）的增殖，从而导致自身免疫性疾病的发生如牛皮癣、类风湿关节炎（RA）等。这些疾病的特点就是会角质细胞和滑膜增生。 PI3K/Akt/mTOR信号级联在细胞生长和存活中起着至关重要的作用。

Find more information on the Altmetric Attention Score and how the score is calculated. Inhibition of phosphoinositide 3-kinase (PI3K) signaling is an appealing approach to treat brain tumors, ...

Rabbit polyclonal antibodies against AKT, pAKT (Ser473), caspase 3 and 9, Cbl, JAK2, pJAK2(Tyr1007/1008), Lyn, pLyn(Tyr396), Hck, and PARP, PI3K p85 STAT5, pSTAT5(Tyr694), were obtained from Cell ...

Taken together, we showed that knockout of PDK1 indirectly alters the PI3K/PDK1 signaling axis by regulating gene transcription of Lyn, PI3K subunits and phosphoinositide-modifying enzymes.