Liver X receptors (LXRs) are nuclear receptors that function as intracellular cholesterol sensors, orchestrating a complex network of genes involved in lipid metabolism, cholesterol homeostasis ...

Find more information on the Altmetric Attention Score and how the score is calculated. Tertiary sulfonamides were identified in a HTS as dual liver X receptor (LXR, NR1H2, and NR1H3) ligands, and the ...

metabolism and the Hippo pathway plays a role in pathogenesis of liver diseases. Here the authors show that the transcriptional coactivator YAP exerts a repressor role on Farnesoid X receptor (Fxr ...

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Trained immunity is a form of innate immune cell memory that is being developed as a novel immunotherapeutic approach for cancer treatment.

Background Current treatments with tyrosine kinase inhibitors and immune checkpoint inhibitors have limited efficacy for ...

Hepatitis C virus (HCV) infection is highly associated with the development of metabolic dysfunction-associated steatotic ...

Primary sclerosing cholangitis, PSC in short, is a rare liver disease that destroys the bile ducts. It is a severe condition ...

Multiple sclerosis (MS) includes both peripheral and central nervous system (CNS) inflammation, and an anti-inflammatory ...

A new American Diabetes Association consensus statement provides guidance on screening, diagnosing, and managing metabolic dysfunction–associated steatotic liver disease.

Improves fibrosis and steatohepatitis Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a broad clinical spectrum, ranging from simple steatosis to metabolic ...

Weight-loss drugs like Ozempic and Wegovy are used by more than 15 million adults in the U.S., or 4.5% of the population.