Three impurities ranging from 0.08%-0.12% by peak area in anastrozole active pharmaceutical ingredient were detected by simple isocratic reverse-phase high performance liquid chromatography (HPLC).

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Anastrozole 0.5 or 1mg was administered after a 10-hour fast. Each point is the mean±SD for six participants. However, in the 1mg treatment group, the points at 72 and 96 hours are the means±SD ...

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