脂质ROS会激活一种相对较新发现的依赖于铁的细胞死亡类型，称为铁死亡（ferroptosis）。这进一步提示着铁死亡与IBD之间的关联，Shah实验室通过分析IBD组织中的RNA表达数据，发现IBD组织和非IBD组织中与铁死亡相关的基因表达存在差异— ...

Breast cancer, particularly triple-negative breast cancer (TNBC), remains a leading cause of cancer-related mortality due to ...

Breast cancer, particularly triple-negative breast cancer (TNBC), remains a leading cause of cancer-related mortality due to its aggressive nature and ...

New basic science insights into programmed cell death could offer relief for inflammatory bowel disease. Many people with IBD ...

Many people with IBD, an umbrella term that includes ulcerative colitis and Crohn's disease, have a reduced quality of life, ...

Chinese scientists have developed a novel nanotherapy known as biomimetic extracellular vesicle spherical nucleic acids ...

Walnuts and almonds can lower blood pressure, reduce inflammation, and reduce the risk of heart disease. The better choice ...

BPM31510 provides encouraging evidence of the potential for transformative benefit for a disease with high unmet need, supporting further development. The Company plans to seek guidance in Q3 2025 ...

Verve Therapeutics’ in vivo base editing therapy, VERVE-102, lowered bad cholesterol in Phase Ib, the company announced Monday morning, leaving the company’s partner, Eli Lilly, with a decision to ...

The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. Cell Metab. 2017 Nov 7;26(5):719-737.e6. Epub 2017 Sep 28 PubMed.

High ROS in neurons causes lipid production and the export of toxic peroxidated lipids (LPOs). Glia uptake these LPOs and incorporate them into lipid droplets (LDs) for storage and catabolism. We ...

Here, we use a combination of isolated mitochondrial assays and in vivo I/R surgery in mice. We challenged isolated liver and heart mitochondria with Ca 2+, ROS, and Fe 2+ to induce mitochondrial ...