A new lipid-based pathway essential for memory formation has been discovered by University of Queensland researchers – a ...

Figure 4: Schematic of a pathway that characterizes a therapy-resistant mesenchymal cancer cell state and its dependency on lipid peroxide dissipation. Dysregulation of the apoptotic cascade is ...

a mitochondrial enzyme that normally is involved in the pyrimidine biosynthesis pathway. In cells with low GPX4 expression, loss of DHODH activity led to the accumulation of lipid peroxides in ...

This pathway centers on the synthesis, storage and use of long-chain polyunsaturated fatty acids, which are susceptible to becoming reactive lipid peroxides. During the process, GPX4 breaks up ...

such as proteins and lipids. That is why we were amazed to find that in cells lacking either glutathione or glutathione peroxidase 4, a distinctive signaling pathway is engaged, which causes cell ...

and they analyzed the role of the TGF-β signaling pathway in regulating lifespan, immunity, and lipid metabolism in Caenorhabditis elegans. The study is published in the journal Nature ...

The results indicate that the complexity of sterol metabolism could have resulted from the need to balance lipid interactions required for membrane organization "This has been one of my favorite ...

UT Southwestern researchers have discovered a molecular pathway that allows cells to sense when their lipid supplies become depleted, prompting a flurry of activity that prevents starvation. The ...