Lipid peroxides are oxidative degradation products ... Ferroptosis is regulated by amino acid metabolism. Here, authors show that the methionine-SAM-UQ axis is responsible for mtROS generation ...

In amyotrophic lateral sclerosis (ALS), dysfunctions in lipid metabolism and function have been identified as potential drivers of pathogenesis. In particular, aberrant lipid metabolism is proposed to ...

which mitigate the negative effects of lipid peroxidation through different pathways. In the following sections, we will discuss each mechanism in detail, along with its potential clinical ...

Human cells have 25 different selenoproteins. These antioxidant enzymes help convert dangerous ROS, such as lipid peroxides, into a safer form. Buildup of lipid peroxides can affect critical cells ...

Hepatocytes, as the most abundant cell type in liver, are a potent source of fibrogenic lipid peroxides in inflammatory liver diseases. Platelets are a potent source of growth factors, and are ...

This knockout negatively impacted hematopoietic stem cells and B cell-lineage immune cells, which was driven by the lack of selenoprotein-mediated fighting of lipid peroxides. These phenotypes ...

Additionally, key amino acid metabolic pathways, including alanine, aspartate and glutamate metabolism (FDR=0.003), and arginine and proline metabolism (FDR=0.002), were disrupted. Furthermore, lipid ...

Human cells have 25 different selenoproteins. These antioxidant enzymes help convert dangerous ROS, such as lipid peroxides, into a safer form. Buildup of lipid peroxides can affect critical cells ...

College of Food Science and Engineering, Northwest A&F University, Yangling 712100, P. R. China ...