DNA transformation and plasmid transformation are the same thing: the uptake of genetic material from the environment by “competent” cells. However, linear DNA is either incorporated into the host ...

A new study in Nature Plants reveals that DNA double-strand break repair (DSBR) pathways help prevent gene transfer from organelles to the nucleus in plants. Disruption of DSBR increases the risk of ...

New findings suggest the end-replication problem, an old standby of biology textbooks, is twice as intricate as once thought. Half a century ago, scientists Jim Watson and Alexey Olovnikov ...

This revolutionary technology represents a significant advancement in synthetic DNA manufacturing, offering a cell-free, enzymatic process to generate linear DNA (linDNA) templates for in vitro ...

Applied DNA Sciences is undergoing a strategic transformation, exiting non-core segments to focus on its LineaRx subsidiary and GMP manufacturing capabilities. With the successful certification of ...

To my surprise, this linear form of SV40 DNA was infectious. But when I recovered the SV40 DNA and looked at it, it was no longer linear. It had become super-coiled circular DNA again. And the EcoRI ...

The manuscript, "A Linear DNA Vaccine Candidate Encoding the SARS-CoV-2 Receptor Binding Domain Elicits Protective Immunity in Domestic Cats," is available in preprint on bioRxiv and will be ...

Beginning in Q1 of 2023 we will release additional BioXp kits that enable scientists to begin the cloning, amplification, and mRNA synthesis process from the customers own linear DNA or plasmid DNA.

To summarize, the intramuscular delivery of the novel linear DNA SARS-CoV-2 vaccine aided by electroporation was determined to be safe and elicited humoral and cellular immune responses.