and lamin B receptor (Lbr) are essential for holding silent genes in their correct position at the edge of the nucleus, in the form of heterochromatin. A deviation from their normal position will ...

“This exciting paper is relevant to AD and related tauopathies, where we see a general loss of heterochromatin and alterations in the lamin nucleoskeleton,” Bess Frost, University of Texas Health, San ...

They disrupted the gene encoding CEC-4, the protein that anchors heterochromatin. The loss of this protein was sufficient to suppress all the phenotypes correlated with the mutant lamin ...

and lamin B receptor (Lbr) are essential for holding silent genes in their correct position at the edge of the nucleus, in the form of heterochromatin. A deviation from their normal position will ...

Heterochromatin, sometimes known as the “dark side of the genome,” is a poorly studied fraction of DNA that makes up about half of our genetic material. For more than 50 years scientists have ...

We prospectively studied patients with genetically proven lamin A/C gene mutations; between March 1999 and January 2004, all patients referred to a participating center for permanent cardiac ...