Cardiac fibroblasts (CF) can become activated and produce excessive extracellular matrix, contributing to fibrotic remodeling ...

Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China Key Laboratory of ...

This important study explored a molecular comparison of smooth muscle and neighboring fibroblast cells found in lung blood vessels afflicted by a disease called pulmonary arterial hypertension. In ...

U.S. Cellular announced nearly 500 layoffs across Iowa, but the company told federal officials that many of those workers could land jobs at T-Mobile as part of an acquisition deal. Iowa's Worker ...

Singapore Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore Department of Diagnostic Radiology, ...

In contrast, a dual FPR1/FPR2 agonist failed to improve joint inflammation. Further analysis revealed common myeloid cell and fibroblast subtypes in the joints and heart that were targeted by the ...

The findings have been reported in The Journal of Clinical Investigation. SCI affects an estimated 18,000 Americans ... But in this work, the researchers wanted to take advantage of cell-free DNA ...

Using cell and zebrafish models, we tested the effects of variants in newly implicated genes. We have characterized the broad genetic architecture of CODE disorders in a large case series of ...

A total of 209 patients received upadacitinib at a dose of 15 mg, 107 received upadacitinib at a dose of 7.5 mg, and 112 received placebo; 70% of the patients had new-onset giant-cell arteritis ...

However, the precise mechanisms through which saccharin can impact bacteria have remained elusive. In this work, we demonstrate that saccharin inhibits cell division, leading to cell filamentation ...

Sotatercept, a first-in-class novel activin-signaling inhibitor, led to a 76% lower risk of a composite of death from any cause, lung transplantation or hospitalization for worsening pulmonary ...