When the macrophages’ ability to consume dying cancer cells or Upd3 production was decreased, tumor growth was significantly ...

Scientists at Nagoya University in Japan studied what happens when macrophages—a type of immune cell—encounter dying cancer ...

When cancer cells die, macrophages consume them and produce inflammatory cytokines. This activates JAK and STAT proteins in ...

Scientists at Nagoya University in Japan studied what happens when macrophages—a type of immune cell—encounter dying cancer cells in tumors and ...

2025年5月，胡琼依副研究员在Blood【IF21.1，Q1】杂志在线发表题名为“Ruxolitinib Targets JAK-STAT Signaling to Modulate Neutrophil Activation in Refractory Macrophage ...

近年研究发现，巨噬细胞在ipf中扮演着"双面角色"：早期表现为促炎表型（m1型），分泌tnf-α、il-6等加剧炎症；后期则转化为促纤维化表型（m2型），通过分泌spp1、arg-1等因子激活肌成纤维细胞。这种极化转换受jak-stat信号通路精密调控，但具体机制尚未阐明。

Inflammation and tumorigenesis are intricately connected processes with significant overlap in their underlying mechanisms. Chronic inflammation is now ...

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