School of Chemistry and Chemical Engineering, State Key Laboratory of Advanced Chemical Power Sources, Chongqing University, Chongqing 400044, China ...

Materials Electrochemistry Group, Department of Materials Science and Engineering, Drexel University, Philadelphia, Pennsylvania 19104, United States ...

Potassium channels are ion channels that are selective for passage of potassium ions through the pore. Potassium channels are homotetramers and are crucial for membrane hyperpolarization events ...

For this article, author Jennifer Fisher Wilson interviewed Roderick MacKinnon, Howard Hughes Medical Institute investigator and head of the Laboratory of Molecular Neurobiology and Biophysics at ...

Image: Courtesy of Roderick MacKinnon MAPPING THE PATH: The transmembrane pore of K+ channels is composed of four identical subunits, of which two are shown. The ion pathway contains a narrow ...

Aug. 31, 2023 — Ion channels are attractive drug targets due to their importance in health and disease, but finding ways to target a specific ion channel selectively is a major challenge. Now ...

Ion channels play a crucial role in a variety of physiological and pathological ... (2023), the researchers utilized deep docking-facilitated VS in conjunction with the VirtualFlow platform to screen ...

Specifically, a wide variety of ion channels, including the strongly inward rectifier potassium (Kir2) channel, require a specific local lipid microenvironment to properly function (22). The ...

Voltage-activated potassium (Kv ... ray structures of detergent-solubilized Kv channels appear to have captured an open state even though a non-conducting C-type inactivated state would predominate in ...