It is important to check whether an expressed membrane protein is successfully secreted to the cell surface. Extracellular protease digestion of intact cells followed by immunoblotting is easy and ...

In the inactive conformation, the a-subunit of the G protein binds to GDP and is bound to a beta-gamma complex (a). Upon receptor activation by its ligand, there is an exchange of GDP for GTP (b).

Adenosine deaminase 2 (ADA2) plays a critical role in immune regulation, particularly in monocyte differentiation and ...

New proteins involved in regulating the cell membrane. ScienceDaily . Retrieved July 12, 2025 from www.sciencedaily.com / releases / 2024 / 09 / 240913105321.htm ...

The synaptotagmin proteins are calcium sensors that activate the release of chemical messengers, dubbed as neurotransmitters that are used by the nerve cells to communicate when calcium ions are ...

Most cells in the body send out little messengers called extracellular vesicles that carry proteins, lipids, and other bioactive molecules to other cells, playing an important role in ...

The tissue in our body can only hold together if the cells adhere not only to each other, but also to extracellular ...

Targeted protein degradation (TPD) is a promising therapeutic strategy that repurposes machinery within the cell to target faulty proteins for destruction. One such technology, lysosome-targeting ...

Membranes of cells are made of lipids and proteins, and they serve barrier functions for cells and intracellular organelles. ... Oct. 24, 2022 — Membrane proteins are key targets for many drugs.

Legionella takes control of host membranes. Some intracellular bacteria, such as Legionella pneumophila, inhabit membrane-bound compartments inside host cells (1).Once there, the microbes typically ...

A group of researchers at the VIB‑UGent Center for Medical Biotechnology has developed a new platform to isolate and analyze ...

An international collaborative study led by U.S and Chinese scientists was the first to show that the extracellular autophagy regulator, sequestosome-1 (SQSTM1), mediates septic death in mice by ...