In a recent study on the medRxiv* preprint server, researchers identified an interleukin 6 (IL-6) dependent alternative pathway as a therapeutic strategy against coronavirus disease 2019 (COVID-19).

Interleukin-6 Signaling Pathways and Functions Publication Trend The graph below shows the total number of publications each year in Interleukin-6 Signaling Pathways and Functions.

Interleukin-6 is also thought to play a role in autoimmunity. Studies of Crohn’s disease patients suggest that IL-6 trans-signaling via the STAT3 pathway protects autoreactive T cells from ...

1,2 However, because blocking inflammatory pathways raises the possibility ... for mediating inflammation in Covid-19 has been interleukin-6, a cytokine produced by macrophages that induces ...

Consequently, various cytokines have been implicated in the pathogenesis of cervical cancer, among which interleukin ... 3-K/Akt pathways (Hirano et al., 1997). The diversity of IL-6 signaling ...

Back to Healio The interleukin-6 pathway has been on the radar of the rheumatology community as an important marker and a target for therapy, perhaps most notably since the FDA approval of ...

We evaluated tocilizumab and sarilumab in an ongoing international, multifactorial, adaptive platform trial. Adult patients with Covid-19, within 24 hours after starting organ support in the ...

"These large-scale and highly consistent results . . . provide solid evidence for a causal role of the proinflammatory interleukin-6 pathway in determining risk of CHD." Commenting on the first ...

noninflamed intestinal tissue, suggesting the IL-6/Th17 pathway is involved in immune ... in other studies include tumor necrosis factor. Interleukin-1-beta, myeloid cells and T resident memory ...

In the experiments, researchers used T cells of various genetic backgrounds and also used various biological inhibitors, such as antibodies against interleukins or against interleukin receptors.