Integrin alpha M, also referred to as ITGAM, is a cell surface receptor protein classified within the integrin family. Integrin ITGAM/ITGB2 is involved in a variety of adhesive interactions among ...

Introduction: Integrin α5β1, a subtype of integrin family, is strongly upregulated on tumor cells ... Methods: There are two main structural units in PR_b, the main recognition site RGDSP and the ...

Abstract: In this paper, we propose a novel clustering and motif modeling framework for analyzing large number of protein family using k-mer. Our approach of using k-mers utilizes both occurring ...

This study aimed at evaluating the expression of integrin family genes in the skin tissue from SSc patients and exploring the potential pathogenic mechanism. Methods: We utilized the public datasets ...

DUBLIN--(BUSINESS WIRE)--The "Integrin Alpha 4 (CD49 Antigen Like Family Member D or VLA4 Subunit Alpha or CD49d or ITGA4) - Pipeline Review, H1 2019" drug pipelines has been added to ...

In this study, the main question was how co-presentation of hyaluronan (HA), an essential component of the extracellular matrix (ECM), and the RGD motif affect integrin binding. We report a method to ...

Introduction: Cardiac fibroblasts are key regulators of the extracellular matrix (ECM), which forms the mechanical environment for cardiomyocytes through extensive integrin binding.

“This is a tremendously exciting time in drug development, when scientific understanding has advanced significantly, creating a clear path forward for effective targeting of the integrin family using ...