Individual response to small-molecule drugs is variable; a drug that provides a cure for some may confer no therapeutic benefit or trigger an adverse reaction in others. To begin to understand ...

Even though individual differences in drug response can result from the ... Pharmacologists classify pathways of drug metabolism as either phase I reactions (i.e., oxidation, reduction, and ...

After all, a medication ideally ought to destroy only tumour cells. However, if the effect of a drug is known only as a statistical average of a larger cell population, an analysis of the drug’s ...

Individual differences in the brain. If selection reinforces a behavior, brain activities soon change as well. August 06, 2020. ... "The ratio of cell activity in these two brain regions could ...

Tailoring medicines to an individual’s genetic profile is now possible. One critical aspect is genetic testing that reduces ...

However, differences in drug response among patients are common, often leading to challenges in optimizing a dosage regimen for an individual patient. Most major drugs are effective in only 25 to ...

Expert Rev Clin Pharmacol. 2008;1(5):695-705. The quality of spontaneous reports is also very important for the proper evaluation of drug safety signals and it is preferable to have a small number ...

In a recent study published in Therapies, researchers presented an overview of sex-based differences in adverse drug reactions (ADRs) based on epidemiology, technique, and underlying mechanism ...

Scientists, finding more evidence that women and men respond differently to drug trials, are pushing the government to create a permanent, national database of gender-based differences in ...

Objective: To replicate and to critique a recently published meta-analysis [1] of the incidence of nonpreventable serious and fatal adverse drug reactions (ADRs) in hospitalized patients, to ...