Individual response to small-molecule drugs is variable ... benefit or trigger an adverse reaction in others. To begin to understand such differences systematically, we treated 104 genotyped ...

Even though individual differences in drug response can ... also been applied — with equal success — to reactions involving phase II drug metabolism. It is interesting to contrast the test ...

In 2,483 distinct combinations of drugs and adverse drug reactions, discrepancies were found 363 times (15 percent). In 89 percent, the reports related more often to women.

We wanted to figure which enzymes within the human body are responsible for metabolizing the drug, because there were some observed inter-individual differences between people in terms of the levels ...

In addition to sex gender differences in drug metabolism may play a role in increasing Adverse drug reactions in women. Female specific issues such as pregnancy, menopause, menstruation may have ...

These findings may help to explain individual differences in the effectiveness and side-effect profiles of therapeutic drugs and thus have implications for personalized medicine. Researchers at ...

Objective: To replicate and to critique a recently published meta-analysis [1] of the incidence of nonpreventable serious and fatal adverse drug reactions (ADRs) in hospitalized patients ...

Although these differences are now widely acknowledged, they are not fully understood. And women are often worse off as a result. This is the case for prescription drugs. Women experience around 50-75 ...

The study found widely varying responses in rats, revealing that individual reactions ... during drug use with an aversive ...